Data were reviewed of the around three-method ANOVA that have pairwise assessment followed by Tukey’s post hoc shot

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March 26, 2022
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Data were reviewed of the around three-method ANOVA that have pairwise assessment followed by Tukey’s post hoc shot

Associations

The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.

Analytical details

Suggest SBP in accordance with urinary sodium in order to potassium (Na + /K + ) removal ratio during evaluating and with weight-loss input away from Weightloss Methods to End Blood pressure levels (DASH) highest sodium (HS) and you can lowest sodium (LS) diet for the (a) salt sensitive and painful (n = 71), (b) salt unwilling (letter = 119) anybody, thinking found because the mean ± SD.

Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).

Next, numerous studies have suggested that hypertension cures evoked by the K + intake could be dependent on dieting Na + intake [28, 29]. Inside our analysis of one’s Dash-Sodium dataset we observed no connection having urinary K + excretion and you may SBP, when you look at the patient examination go to or during Dashboard weight-loss input whenever Na + consumption is actually altered, indicating a liberty of your own effects of Na + and you will K + towards the SBP within this research. The 2019 DRI Statement determined that there’s shortage of proof into the the effects out-of K + to your blood pressure level and you will didn’t present good DRI out-of K + . The research hold the 2019 DRI Statement and you may implies that losing weight K + supplements might not notably reduce blood pressure in the general people.

Summation

Stamler J, jak wysÅ‚ać komuÅ› wiadomość na snapsext Rose Grams, Stamler R, Elliott P, Dyer A beneficial, Marmot Meters. INTERSALT study results. Public health insurance and health care ramifications. Hypertension. 1989;–seven.

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